📄 Category

psychiatry and clinical psychology

178 papers

Suppression of Endogenous Alpha Power Predicts Clinical Response to 10 Hz tACS in Major Depressive Disorder: A Double-Blind Randomized Controlled Trial

In a double-blind randomized controlled trial, while 10 Hz tACS did not significantly outperform sham in altering prefrontal alpha power overall, clinical improvement in major depressive disorder was specifically predicted by the suppression of endogenous alpha power at individual alpha frequencies, supporting the personalization of tACS parameters for future treatments.

Schwippel, T., Pupillo, F., LaGarde, H. + 4 more2026-03-19📄 psychiatry and clinical psychology

Witnessing Trauma in the Modern Era: The Role of Uncensored Media in Mental Health

This study demonstrates that among individuals not directly exposed to the October 7th, 2023 collective trauma, greater consumption of uncensored graphic media content via social networks is a distinct and significant predictor of increased post-traumatic stress disorder (PTSD) symptom severity, independent of other risk factors such as mental health history and social support.

Allouche-Kam, H., ELHASID FELSENSTEIN, T., Arora, I. H. + 4 more2026-03-18📄 psychiatry and clinical psychology

Impact of Breast Cancer on Body Image: A Systematic Review and Meta-Analysis

This systematic review and meta-analysis of 41 studies demonstrates that breast cancer and its treatments, particularly mastectomy, significantly impair women's body image compared to healthy controls and pre-treatment states, underscoring the critical need to integrate body image support into comprehensive care plans.

Yazici Sarikaya, S., Wang, R., Kimmig, A.-C. S. + 4 more2026-03-18📄 psychiatry and clinical psychology

Cognition and Electrophysiology Clustering in Clinical High Risk for Psychosis Delineates Distinct Dimensions of Heterogeneity: Implications for Multimodal Clustering

Using unsupervised clustering on combined cognitive and electrophysiological data from the NAPLS 2 and 3 cohorts, this study identifies a distinct CHR subgroup characterized by poorer cognition, larger ERP amplitudes, and worse functioning, while concluding that multimodal clustering without developmental considerations may obscure meaningful subtyping.

Yassin, W., Green, J. B., Cai, M. + 24 more2026-03-17📄 psychiatry and clinical psychology

A qualitative investigation of young peoples experiences and views of Early Support Hubs

This qualitative study of 20 young people in England found that Early Support Hubs are valued for their accessible, holistic, and youth-led approach to mental health support, though they face challenges regarding limited awareness, capacity for complex needs, and the need for further evidence to justify wider implementation.

Wright, L., Griffiths, J., Appleton, R. + 17 more2026-03-16📄 psychiatry and clinical psychology

Integrative, and Scalable mental health phenotyping using a knowledge-graph-derived dual-metric framework

This study introduces a scalable mental health phenotyping framework that utilizes a knowledge graph-derived dual-metric system (Cognitive Attention Score and C:ERR), grounded in yogic psychology and lifestyle factors, to provide a multidimensional, validated alternative to traditional symptom-focused diagnostic instruments.

Sharma, A., Bharadwaj, A., Modi, S. + 3 more2026-03-16📄 psychiatry and clinical psychology

Childhood Mental Health and Body Mass Index as Mediators of Genetic Risk for Eating Disorders

This longitudinal study of over 5,000 children reveals that genetic liabilities for anorexia nervosa and binge eating contribute to early disordered eating behaviors through distinct metabolic and psychosocial pathways, with BMI mediating risks across sexes and ADHD or anxiety/depression symptoms serving as additional mediators specifically in females.

Liu, C., Xu, J., Kepinska, A. + 6 more2026-03-16📄 psychiatry and clinical psychology

Pilot Randomized Trial of Intermittent Theta-Burst Stimulation versus H-Coil Transcranial Magnetic Stimulation for Treatment-Resistant Depression

This pilot randomized trial found that intermittent theta-burst stimulation (iTBS) and H-coil rTMS demonstrated comparable efficacy in treating treatment-resistant depression over six weeks, with no significant differences in symptom reduction, response, or remission rates, while exploratory analyses suggested a potential link between baseline executive functioning and remission.

Desbeaumes Jodoin, V., Bousseau, E., Trottier-Duclos, F. + 10 more2026-03-16📄 psychiatry and clinical psychology

A twin-aware multimodal deep learning framework with optimized late fusion for early prediction of adolescent anxiety disorder

This study proposes a twin-aware multimodal deep learning framework that integrates neuroimaging, behavioral, and phenotypic data via optimized late fusion to achieve robust early prediction of adolescent anxiety disorders, demonstrating an 11% performance gain over unimodal baselines with a final AUC of 0.8935.

Taosif, M., Chaman, U. M., Prova, N. A. + 3 more2026-03-16📄 psychiatry and clinical psychology

Shared genetic architecture between anorexia nervosa and metabolomic biomarkers suggest underlying causal pathways

This study reveals that anorexia nervosa shares a distinct genetic architecture with 142 metabolomic biomarkers, particularly lipid-related ones, which are driven by developmental and inflammatory processes and linked to cardiometabolic traits through a causal pathway mediated by body mass index (BMI).

Makowski, C., Shadrin, A., Stinson, S. E. + 6 more2026-03-13📄 psychiatry and clinical psychology

Third places visits and well-being: insights from longitudinal passive sensing data

Using a year-long longitudinal study of 410 medical residents with passive sensor data, this research demonstrates that spending more time in and visiting a greater number of "third places" is bidirectionally associated with improved daily mood and reduced depression, partially mediated by physical activity and outdoor light exposure.

Fang, Y., Saulnier, K., Cleary, J. + 3 more2026-03-13📄 psychiatry and clinical psychology

Building a prediction model for outcomes following treatment in UK NHS Talking Therapies services for depression and anxiety

This study developed and internally validated multivariable prediction models using routine data from nearly 31,000 UK NHS Talking Therapies patients to identify key predictors of treatment outcomes for depression and anxiety, demonstrating the potential for data-driven tools to support personalized care and early intervention for those at risk of poor recovery.

Kanso, N., Skelton, M., Rimes, K. A. + 3 more2026-03-13📄 psychiatry and clinical psychology

Baseline Inflammatory Profiles in Moderate-to-Severe Depression and Differential Response to Intermittent Theta-Burst Stimulation

This exploratory study demonstrates that baseline inflammatory protein signatures, particularly those involving cytokine and chemokine signaling pathways, can stratify patients with moderate-to-severe depression into distinct subgroups with differential responsiveness to intermittent theta-burst stimulation (iTBS), suggesting a potential biomarker-driven approach for personalized psychiatric treatment.

Pedraz, B., Wilkening, J., Ziegler, N. + 3 more2026-03-12📄 psychiatry and clinical psychology

Estimating the genetic distance between subtypes of Major Depressive Disorder and their relationships with other traits using GDIS

This paper introduces GDIS, a novel method that estimates genetic distances and relationships between Major Depressive Disorder subtypes using only summary statistics from subtype-versus-control GWAS, thereby enabling direct subtype comparisons and revealing differential correlations with external traits to advance the understanding of genetic heterogeneity.

Thijssen, A. B., Milaneschi, Y., Bartels, M. + 4 more2026-03-12📄 psychiatry and clinical psychology

A Preoperative Electroencephalography Signature for Predicting Treatment Response to Deep Brain Stimulation in Obsessive-Compulsive Disorder

This study identifies and prospectively validates a preoperative resting-state EEG signature, characterized by lower relative delta-band power in the right fronto-temporal region, as a robust, scalable biomarker for predicting treatment response to deep brain stimulation in patients with treatment-refractory obsessive-compulsive disorder.

Wang, W., Cheng, J., Zhang, X. + 19 more2026-03-12📄 psychiatry and clinical psychology

Transcriptomic Profiling of the Amygdala of Children with Autism Spectrum Disorder

This study utilized RNA sequencing on postmortem amygdala samples from children with Autism Spectrum Disorder to identify dysregulated molecular pathways involving immune signaling, extracellular matrix organization, and synaptic function, subsequently proposing specific drug repurposing candidates such as anti-inflammatory agents and PDGF receptor inhibitors for early intervention.

Babu, J., Lal, A., Challagundla, L. + 4 more2026-03-12📄 psychiatry and clinical psychology

Multi-Criteria Validation of LLM-Inferred Depression Severity from Outpatient Psychiatry Notes

This study demonstrates that a HIPAA-compliant large language model can accurately infer depression severity scores from outpatient psychiatric notes, showing strong agreement with clinical assessments and predictive validity for treatment changes and emergency visits, thereby enabling standardized longitudinal phenotyping for real-world research and routine monitoring.

Cudic, M., Meyerson, W. U., Wang, B. + 5 more2026-03-12📄 psychiatry and clinical psychology

Wellbeing While Waiting: Effectiveness and implementation of youth social prescribing for young people awaiting CAMHS support.

This multisite non-randomised controlled trial demonstrates that social prescribing is a safe and effective adjunct for young people awaiting CAMHS support, significantly improving behavioural difficulties and resilience despite showing no significant impact on anxiety or depression symptoms compared to usual care.

Hayes, D., Wright, J., Burton, A. + 10 more2026-03-12📄 psychiatry and clinical psychology